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KMID : 0043319990220020189
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Archives of Pharmacal Research
1999 Volume.22 No. 2 p.189 ~ p.193
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Identification of IY81149 and Its Metabolites in the Rat Plasma Using the On-Line HPLC/ESI Mass Spectrometry
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Myung Seung-Woon
Min Hye-Ki
Jin Chang-Bae
Kim Myung-Soo
Lee Seung-Mok
Chung Gi-Ju
Park Seong-Jun
Kim Dong-Yeon
Cho Hyun-Woo
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Abstract
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Reversed-phase high-performance liquid chromatography/mass spectrometry (HPLC/MS) with an eletcrospray ionization (ESI) interface was applied to the identification of metabolites of IY81149 in the rat plasma. Fragments obtained using collision-induced dissociation (CID) in both positive and negative modes were utilized to elucidate the structure of metabolites. The eluent from the conventional HPLC column was split and directly introduced into an ESI-mass spectrometer for the identification of the structures. the CID technique allowed the sensitive identification of sulfonyl-IY81149 and hydroxy-IY81149 from the rat plasma.
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KEYWORD
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IY81149, Meatbolites, HPLC, Electrospray ionization (ESI), Mass spectrometry (MS), Collision induced dissociation (CID)
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